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2 edition of Animal models of thrombosis and hemorrhagic diseases found in the catalog.

Animal models of thrombosis and hemorrhagic diseases

Workshop on Animal Models of Thrombosis and Hemorrhagic Diseases National Academy of Sciences 1975.

Animal models of thrombosis and hemorrhagic diseases

by Workshop on Animal Models of Thrombosis and Hemorrhagic Diseases National Academy of Sciences 1975.

  • 347 Want to read
  • 24 Currently reading

Published by National Academy of Sciences in Washington .
Written in English

    Subjects:
  • Diseases -- Animal models -- Congresses.,
  • Hemorrhagic diseases -- Congresses.,
  • Thrombosis -- Congresses.

  • Edition Notes

    Includes bibliographies.

    StatementInstitute of Laboratory Animal Resources, Assembly of Life Sciences, National Research Council.
    ContributionsNational Research Council. Institute of Laboratory Animal Resources.
    Classifications
    LC ClassificationsRC636 .W67 1975, RC636 W67 1975
    The Physical Object
    Paginationxvi, 203 p. :
    Number of Pages203
    ID Numbers
    Open LibraryOL19517199M

    Cattle Disease Guide. This comprehensive disease guide provides information on diseases that can affect individual animals or an entire herd. Typical symptoms associated with the disease will help identify the problem, advice for treatment and measures to prevent disease is also available.   With authoritative coverage of rare and common hemostatic disorders, Consultative Hemostasis and Thrombosis, 4th Edition, keeps you both up to date with all that's new in this fast-moving field as well as reviewing background and development and citing pertinent classical literature. Broad differential diagnoses are provided, underscoring the editors' position that correct treatment Pages:

    In healthy people, homeostatic balance exists between procoagulant (clotting) forces and anticoagulant and fibrinolytic forces. Numerous genetic, acquired, and environmental factors can tip the balance in favor of coagulation, leading to the pathologic formation of thrombi in veins (eg, deep venous thrombosis [DVT]), arteries (eg, myocardial infarction, ischemic stroke), or cardiac chambers. An understanding of thrombosis biology will allow for more effective VT-tailored diagnosis and therapy. In vivo models of thrombosis provide indispensable tools to study the pathogenesis of thrombus formation and to evaluate novel therapeutic or preventive adjuncts for VT management or by: 8.

    Keywords:Anticoagulant, thrombosis, hemophilia, hemorrhage. Abstract: Abnormalities in the hemostatic system can lead to, on one end of the spectrum, hemorrhage, and on the opposite end, thrombosis. Over the past decade, important new agents for the management of hemorrhagic and thrombotic disorders have been developed and more are in by: 4. I am interested in studying the cross-talk between coagulation and inflammation in various animal models of disease, including sickle cell disease, thrombosis, and drug-induced liver injury. My current focus is to target the coagulation cascade and protease activated receptors to reduce the incidence and severity of vaso-occlusive crisis in.


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Animal models of thrombosis and hemorrhagic diseases by Workshop on Animal Models of Thrombosis and Hemorrhagic Diseases National Academy of Sciences 1975. Download PDF EPUB FB2

Animal Models of Thrombosis and Hemorrhagic Diseases Unknown Binding – January 1, See all formats and editions Hide other formats and editions click to open popoverManufacturer: US Dept Health, Education and Welfare.

"The Workshop on Animal Models of Thrombosis and Hemorrhagic Diseases was held at the National Academy of Sciences, Washington, D.C., March"--Preface.

Description: xvi, pages: illustrations ; 23 cm. Suggested Citation:"Front Matter."National Research Council. Animal Models of Thrombosis and Hemorrhagic gton, DC: The National Academies Press.

Suggested Citation:"PUBLIC RELATIONS."National Research Council. Animal Models of Thrombosis and Hemorrhagic gton, DC: The National Academies. Rats, rabbits, dogs, pigs, and monkeys are well-established animal models of atherosclerosis and thrombosis whereas hamster, mouse, cat, and guinea pig have also been used, although to a lesser.

This chapter provides an introduction to the concept of laboratory animal models, focusing on a general classification of animal models for the study of human diseases.

Animal models can be grouped into one of the following five categories: (1) induced (experimental) models, (2) spontaneous (genetic, mutant) models, (3) genetically modified models, (4) negative models, and (5) orphan by: A critical review is presented on animal models of thrombosis.

After a glance at the pathogenesis of clinical thrombosis and its multifactorial charac Cited by: 4. Animal Models for Viral Hemorrhagic Fever. Aimed at studying human diseases, animal models emerged in the s and underwent a real boom during the last century. Acute thrombosis was. Novel treatments that either prevent thrombus formation or hasten resolution without these side effects are desirable, and are likely to arise from a better understanding of the molecular and cellular mechanisms that control venous thrombosis.

Experimental models of DVT have been developed in a variety of animals, including the mouse 4, rat 5, rabbit 6, dog 7, pig 8, and non-human primates 9.

Spontaneous, symptomatic DVT Cited by: 8 Brinkhous K M. Animal models of hemophilia. In: Animal Models of Thrombosis and Hemorrhagic Diseases. Bethesda, MD; National Institutes of Health ; 9 Giles A R, Tinlin S, Greenwood R.

A canine model of hemophilic (factor VIII:C deficiency) bleeding. Blood. Mice, dogs, and pigs are the most commonly used animal models for hemophilia. With the advent of the nuclease method for genome editing, namely the CRISPR/Cas9 system, it is now possible to create animal models for hemophilia other than mice in a short period of by: 5.

Mice and rats are the most commonly used laboratory animals but various other animals like rabbits, gerbils, cats, dogs, pigs and monkeys have been used in different animal models for a thorough understanding of the disease pathology and treatment (Traystman, ).

Owing to their close resemblance with humans in cerebrovascular anatomy and physiology, rats are the most commonly Cited by: Many advances have been made in the field of thrombosis and haemostasis since the publication of the second edition of this book. This thoroughly revised third edition of Practical Hemostasis and Thrombosis encompasses the major progress in the understanding of the genetics and molecular biology, new drugs and treatment regimens available, and updated content on direct oral 3/5(1).

Abstract. Animal experimentation and research with animals is an integral part of clinical research, including surgery. The goal is to solve problems encountered in clinical practice and develop new methods and approaches to the cure and alleviation of disease and disability.

Thrombosis and Bleeding Disorders compiles the laboratory and research aspects of thrombosis and hemorrhagic disorders in humans. This book presents reviews of the underlying theory, physiology, and biochemistry of hemostasis and thrombosis, including the enzymology of blood coagulation and Edition: 1.

t, modeling of this complex response using in-vitro or in-silico strategies is insufficient. The use of animal models of thrombosis provides a critical tool for the discovery and initial testing of novel therapies for vascular thrombosis.

Recent findings The literature from to the present provides significant advances in regard to novel models of arterial thrombosis, novel mechanisms. Crimean-Congo hemorrhagic fever virus (CCHFV) is an important tick-borne human pathogen endemic throughout Asia, Africa and Europe.

CCHFV is also an emerging virus, with recent outbreaks in Western Europe. CCHFV can infect a large number of wild and domesticated mammalian species and some avian species, however the virus does not cause severe disease in these animals, but can produce by: 2.

Author(s): Wessler,S Title(s): Introduction: what is a model?/ S. Wessler. In: Workshop on Animal Models of Thrombosis and Hemorrhagic Diseases ( Washington.

Features of common models of acute lung injury. Many different modeling strategies have been developed in an attempt to reproduce the features of human ALI/ARDS in animals.

From a practical standpoint, there are four general types of model systems: Models in which the lung is injured directly by a noxious stimulus. Recently, there have been substantdevelopments ial in the understanding of Ebola hemorrhagic fever pathogenesis, but there are still major gaps.

These infections occur in underdeveloped areas of the world,and much of our knowledge of naturally occurring disease is derived from sporadic outbreaks that occurred decades in the by:.

Mechanisms of Thrombosis Maureane Hoffman, MD, PhD Professor of Pathology. Blood clotting where it shouldn't or when you don't want it to. Things You Should Know:\r\(1\) Arterial \(and sometimes venous\) Thrombosis and Atherosclerosis \(Plaque Rupture\) - I consolidated things she said throughout the lectures on Slides 2 & 30\r\(2\) Venous Thrombosis and Pulmonary Embolism - Slides 4, 5 & 8\r\.Tao Yan, Michael Chopp and Jieli Chen, Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke, Neuroscience Bulletin, /sz, 31, 6, (), ().Cited by:   / In vivo veritas: Thrombosis mechanisms in animal models.

In: much can be learned from existing models about specific biologic processes in disease causation and therapeutic intervention. In general, large animals such as pigs and monkeys have been better suited to study atherosclerosis and arterial and venous thrombosis than smaller Cited by: